smooth muscle myosins การใช้

• Myosin-11 is a smooth muscle myosin belonging to the myosin heavy chain family.
• CPI-17 is a phosphorylation-dependent inhibitor protein of smooth muscle myosin phosphatase, discovered in pig aortic homogenetes.
• NM-IIB is part of the larger myosin II subfamily of proteins, which also includes skeletal muscle, cardiac muscle and smooth muscle myosins.
• The increase in telokin expression correlated with an increase in the expression of several other smooth muscle-restricted proteins, including smooth muscle myosin and alpha-actin.
• NM-IIB has many properties that are similar to those of smooth muscle myosins, such as the permissive nature of phosphorylation of the 20 kDa regulatory light chain for MLC20 ) phosphorylation.
• The 20-kDa light chain from smooth muscle myosin is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors, but more slowly.
• Because of its origin as the C-terminal end of smooth muscle myosin light chain kinase, it is called " telokin " ( from a combination of the Greek telos, " end " and kinase ).
• It was demonstrated that when a single smooth muscle cell is rhythmically stretched, it shows increased expression of a number of genes ( caldesmon, calpomin, ?-actine, smooth muscle myosin ), along with increased proliferation ability.
• The pericentric inversion of chromosome 16 [ inv ( 16 ) ( p13q22 ) ] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N-terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain.